Efficient Synthesis of Polymeric Fluorinated Nanoparticles with High Fluorine Content via Aqueous Photo-Polymerization-Induced Self-Assembly for <sup>19</sup>F MRI Application
Polymeric fluorinated nanoparticles (PFNPs) are useful materials in many applications, especially in the field of <sup>19</sup>F magnetic resonance imaging (MRI). Despite the development of numerous PFNPs with diverse chemical compositions and structures, those with high fluorine content and capable of highly sensitive <sup>19</sup>F MRI remain scarce. Here we report an elegantly designed aqueous photo-polymerization-induced self-assembly (photo-PISA) system for the synthesis of PFNPs with high fluorine content for effective <sup>19</sup>F MRI applications. This innovative photo-PISA system is enabled by two analogous fluorinated monomers, allowing efficient production of PFNPs with different morphologies and high fluorine content (25 wt %) in aqueous solution. These PFNPs exhibit favorable <sup>19</sup>F MRI properties and morphology-dependent biological behavior, and have potential as advanced polymeric nanomaterials for imaging and drug delivery applications.
Authors
- Andrew K. Whittaker (ORCID: https://orcid.org/0000-0002-1948-8355)
- Yuhao Zhang (ORCID: https://orcid.org/0000-0001-5199-172X)
- Changkui Fu (ORCID: https://orcid.org/0000-0002-2444-607X)
- Amnon Bar‐Shir (ORCID: https://orcid.org/0000-0003-1431-0221)
- Weizhi Xu (ORCID: https://orcid.org/0000-0003-3697-1581)
- Qiaoyun Wang (ORCID: https://orcid.org/0000-0002-9939-8711)
- Gayathri R. Ediriweera (ORCID: https://orcid.org/0000-0002-8782-8745)
- Kun Liu (ORCID: https://orcid.org/0000-0003-2940-9814)
- Hui Peng (ORCID: https://orcid.org/0000-0002-9221-385X)
- Yi-Xin Chang (ORCID: https://orcid.org/0000-0001-5317-7641)
- Xin Xu (ORCID: https://orcid.org/0000-0003-4259-4508)
Institutions
- Australian Research Council (AU)
- The University of Queensland (AU)
- Jilin University (CN)
- Institute of Bioengineering and Nanotechnology (SG)
- Jilin Medical University (CN)
- State Key Laboratory of Supramolecular Structure and Materials
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- ACS Nano
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1021/acsnano.5c00562
- Citations
- 4
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Arthritis Australia
- Australian Research Council
- National Health and Medical Research Council