Hydrogen-Bond-Assisted Ru(III)-Catalyzed C–C Bond Activation in 1,3-Dicarbonyls: A Direct Route to Multi-Substituted Pyrroles
Unprecedented CO-Cα bond cleavage of 1,3-dicarbonyls and enaminone, catalyzed by a well-defined Ru(III)-complex (<b>1</b>) featuring a redox-active triamine ligand (<b>L</b><sup><b>1</b></sup>) with a free -NH<sub>2</sub> arm, opening a new route to accessing substituted pyrroles with broad substrate scope and functional group tolerance in good isolated yields via multicomponent coupling of 1,3-dicarbonyls, amines, and diol, is reported. The hydrogen bonding interaction offered by <b>1</b> facilitates the formation of critical reaction intermediates, favoring the formation of pyrroles.
Authors
- Santana Chakraborty (ORCID: https://orcid.org/0009-0007-4673-0446)
- Nanda Dulal Paul (ORCID: https://orcid.org/0000-0002-8872-1413)
- Arijit Singha Mohapatra
Institutions
- Indian Institute of Engineering Science and Technology, Shibpur (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1021/acs.joc.5c00233
- Citations
- 2
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Science and Engineering Research Board