Biallelic Variants in <scp><i>EPG5</i></scp> Gene Are Associated with Parkinson's Disease
Our results unveil a novel association between biallelic variants in EPG5 gene and PD, providing compelling initial evidence for the involvement of EPG5 and autophagy dysregulation in the development of PD. ANN NEUROL 2025;98:369-385.
Authors
- Lin Wei (ORCID: https://orcid.org/0000-0001-7146-891X)
- Jie Wang (ORCID: https://orcid.org/0009-0002-0566-9865)
- Qian Xu (ORCID: https://orcid.org/0000-0002-5223-9967)
- Runcheng He
- Hongxu Pan (ORCID: https://orcid.org/0000-0003-4255-5904)
- Wei‐Qian Zeng
- Xun Zhou (ORCID: https://orcid.org/0000-0002-7325-5720)
- Sheng Zeng (ORCID: https://orcid.org/0000-0002-9283-6598)
- Jinchen Li (ORCID: https://orcid.org/0009-0002-3893-8128)
- Qiying Sun (ORCID: https://orcid.org/0000-0002-2031-8345)
- Yuwen Zhao (ORCID: https://orcid.org/0000-0001-5020-9134)
- Fu‐Lei Tang (ORCID: https://orcid.org/0000-0003-2102-1137)
- Xinxiang Yan (ORCID: https://orcid.org/0000-0002-4367-7105)
- Jifeng Guo (ORCID: https://orcid.org/0000-0002-3658-3928)
- Beisha Tang (ORCID: https://orcid.org/0000-0003-2120-1576)
- Zhenhua Liu (ORCID: https://orcid.org/0000-0003-1926-6020)
- Dandan Wang (ORCID: https://orcid.org/0000-0001-7234-9517)
- Xuejing Wang (ORCID: https://orcid.org/0000-0003-2908-7763)
- Jian Qiu (ORCID: https://orcid.org/0000-0001-7873-0722)
- Yao Zhou (ORCID: https://orcid.org/0000-0002-9482-4697)
Institutions
- Central South University (CN)
- First Affiliated Hospital of University of South China (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/ana.27242
- Citations
- 8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hunan Province