Characterisation and Management of Non-Invasive Follicular Thyroid Neoplasms with Papillary Nuclear Features (NIFTP): A Case Report of 10 Patients

Introduction : Thyroid cancers, the most common endocrine tumours, have increased in incidence, partly due to advanced diagnostic techniques. Non-invasive follicular thyroid neoplasms with papillary nuclear features (NIFTP) are characterized by a low malignancy risk and excellent prognosis. NIFTP was reclassified in 2015 to prevent overdiagnosis and overtreatment. This study aims to explore the characteristics, management, and outcomes of NIFTP. Methods : This retrospective study, conducted over six years (2018–2024) at Mohammed VI University Hospital Centre, identified 10 NIFTP cases from pathology samples. All patients were referred for management and follow-up in the endocrinology department. Results : The cohort was predominantly female (80%) with a mean age of 56 years. Most patients presented with multinodular goitre or thyroid nodules, with some showing compressive symptoms. Ultrasound revealed multiheteronodular goitre in 80% of cases. All patients underwent total thyroidectomy, and no recurrence was observed during an average follow-up of 18 months. Discussion : NIFTP is associated with a very low malignancy risk and a favorable prognosis. Its diagnosis is based on histopathology, and management typically involves conservative surgery. The reclassification of EFVPTC as NIFTP helps reduce unnecessary treatments. Long-term follow-up and further research are needed to refine patient care strategies. Conclusion : Reclassification of EFVPTC to NIFTP allows for more conservative management, ensuring excellent patient outcomes. Ongoing advances in diagnostic and management techniques will continue to optimize care for these patients.