Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis

<b>Background/Objectives:</b> Retinal vein occlusion (RVO) is a major cause of vision loss globally. Although magnesium (Mg) is crucial for vascular health, its association with RVO risk is unknown. Thus, we aimed to further examine this association. <b>Methods:</b> This cross-sectional study included participants of the Korean National Health and Nutrition Examination Survey 2017-2021 aged ≥19 years (n = 16,358). RVO diagnosis was based on fundus imaging or was self-reported. Based on their daily Mg intake, we categorized participants into low (<120 mg), intermediate (men: 120-300 mg; women: 120-400 mg), and sufficient (men: ≥300 mg; women: ≥400 mg) intake groups and compared their characteristics across groups. <b>Results:</b> RVO prevalence was 0.7%. Compared to the non-RVO group, the RVO group was characterized by older individuals, fewer current alcohol consumers, a higher prevalence of hypertension and chronic kidney disease, and a lower intake of fiber, iron, calcium, vitamin E, and Mg. After full adjustment, sufficient Mg intake was significantly associated with a 64% reduced risk of RVO (odds ratio [OR] 0.36, 95% confidence interval [CI] 0.18-0.71, <i>p</i> = 0.003). This association was particularly notable among individuals aged 19-59 years (OR 0.18, 95% CI 0.04-0.82, <i>p</i> = 0.027), those with hypertension (OR 0.29, 95% CI 0.13-0.67, <i>p</i> = 0.003), and those without glaucoma (OR 0.33, 95% CI 0.15-0.71, <i>p</i> = 0.004). <b>Conclusions:</b> Sufficient Mg intake may reduce RVO risk among adults aged <60 years, individuals with hypertension, and those without glaucoma. Further research should validate the benefits of Mg supplementation in preventing RVO.