Associations of circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the expression of stem cell markers in benign breast tissue
Higher circulating IGFBP-3 levels were associated with lower stromal CD24 expression in benign breast tissue. Our findings provide indirect evidence of the inducing effect of IGF pathway on epithelial-to-mesenchymal transitions and stem cell activity in the breast.
Authors
- Yujing Jan Heng (ORCID: https://orcid.org/0000-0002-8930-817X)
- Kornélia Polyák (ORCID: https://orcid.org/0000-0002-5964-0382)
- Divya Murthy (ORCID: https://orcid.org/0009-0007-9555-8419)
- Barbara Sardella
- Lusine Yaghjyan (ORCID: https://orcid.org/0000-0002-1626-5340)
- Rulla M. Tamimi (ORCID: https://orcid.org/0000-0003-2306-8668)
- Matt B. Mahoney (ORCID: https://orcid.org/0009-0003-1179-9292)
- BERNARD A. ROSNER (ORCID: https://orcid.org/0000-0001-6907-0056)
- Maisey Ratcliff
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Cornell University (US)
- University of Florida (US)
- Dana-Farber Brigham Cancer Center (US)
- Weill Cornell Medicine (US)
- Florida College (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s13058-025-02002-z
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Avon Foundation for Women
- Susan G. Komen for the Cure
- Breast Cancer Research Foundation
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Cancer Institute