Cover Feature: Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group (Chem. Eur. J. 20/2025)

Nitrocyclopropanes, a special class of donor–acceptor cyclopropanes, are considered to be stepping stones in organic synthesis. Due to the versatile nature of the nitro group, they can be converted into other functional heterocyclic or scaffolds of higher structural complexity to provide access to biologically active molecules. In their Review (DOI: 10.1002/chem.202404791), A. G. Chaidali, M. A. Terzidis and I. N. Lykakis have gathered and categorised the various synthetic methodologies based on the origin of the nitro group. The results of an application-focused analysis highlight the importance of nitrocyclopropanes as key intermediates.