(+)-Terrein exerts anti-obesity and anti-diabetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet
This study demonstrated that (+)-terrein effectively induces PPARγ expression and brown adipocyte differentiation, leading to reduced weight gain and improved glucose and lipid profiles in HF-fed mice. Thus, (+)-terrein is a potent novel agent with potential anti-obesity and anti-diabetic properties.
Authors
- Tsutomu Sasaki (ORCID: https://orcid.org/0000-0001-8041-1915)
- Shuichi Okada (ORCID: https://orcid.org/0000-0003-1403-6840)
- Tsugumichi Saito (ORCID: https://orcid.org/0000-0002-3189-2561)
- Hiroki Mandai (ORCID: https://orcid.org/0000-0001-9121-3850)
- Takashi Nakakura (ORCID: https://orcid.org/0000-0003-1898-563X)
- Haruka Aoki‐Saito (ORCID: https://orcid.org/0000-0002-4303-330X)
- Kazuhiro Omori (ORCID: https://orcid.org/0000-0002-4129-1401)
- Tadahiro Kitamura (ORCID: https://orcid.org/0000-0001-8809-8740)
- Takeshi Hisada (ORCID: https://orcid.org/0000-0002-3862-1887)
- Seiji Suga (ORCID: https://orcid.org/0000-0003-0635-2077)
- Masanobu Yamada (ORCID: https://orcid.org/0000-0002-2142-633X)
Institutions
- Tokyo Gakugei University (JP)
- Okayama University (JP)
- Gunma University (JP)
- Kyoto University (JP)
- Gifu University of Medical Science (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.biopha.2025.118030
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.49