Next-generation sequencing in early-stage multiple primary lung cancer: The prognostic significance of genomic accumulation status and BCL2L11del
The prognosis of patients with early-stage MPLC may potentially be related to the accumulation status of gene mutation series and sites; their driving powers may offset each other. Taken together, the application of genomic profiling may prove to be useful for subdividing and precisely managing patients with MPLC. In addition, high expression of PRMT8 presented as an independent prognostic biomarker in lung cancer patients harboring the BCL2L11<sup>del</sup> mutation.
Authors
- Yanqi Lu (ORCID: https://orcid.org/0000-0002-1181-3176)
- Chen-Hui Ni
- M Wang
- Maohui Chen (ORCID: https://orcid.org/0000-0001-6931-8875)
- Chun Chen (ORCID: https://orcid.org/0000-0001-9264-8020)
- Bin Zheng (ORCID: https://orcid.org/0000-0001-8429-5384)
- Shuliang Zhang (ORCID: https://orcid.org/0000-0003-2320-7912)
- Weitao Zheng (ORCID: https://orcid.org/0000-0002-9028-278X)
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.tranon.2025.102383
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00