Salvage therapies for first relapse of SHH medulloblastoma in early childhood

Survival of patients with relapsed SHH iMB is not satisfactory and relies on treatments associated with toxicities including CSI and/or HDC + AuHCR. Cure at initial diagnosis to avoid relapse is crucial. For patients with localized relapse undergoing resection, alternative salvage regimens that avoid high-dose CSI (>24 Gy) can be considered.

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Publication Details

Journal
Neuro-Oncology
Published
2025-04-05
DOI
https://doi.org/10.1093/neuonc/noaf092
Citations
2
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
3.25
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article

Salvage therapies for first relapse of SHH medulloblastoma in early childhood

Ashley Margol, Christelle Dufour, Nisreen Yousef Amayiri, Stefan Rutkowski et al.
2 citations
Neuro-Oncology
Glioma Diagnosis and Treatment
3.25
article

Salvage therapies for first relapse of SHH medulloblastoma in early childhood

Ashley Margol, Christelle Dufour, Nisreen Yousef Amayiri, Stefan Rutkowski, Marie Simbozel, Lorena Baroni, Svenja Tonn, Sylvia Cheng, Juliette Hukin, Chantel Cacciotti, Shafqat Shah, Jordan R. Hansford, Gudrun Fleischhack, Álvaro Lassaletta, Craig Erker, Virginia L. Harrod, Nicolas U. Gerber, Kathleen Dorris, Amar Gajjar, Jeffrey C. Murray, Vijay Ramaswamy, Lucie Lafay‐Cousin, Ralph Salloum, Kenneth J. Cohen, George Michaiel, Dolly Aguilera, Giles W Robinson, Brandon T. Craig, Stephen W. Gilheeney, Cassie Kline, Vicente Santa‐María López, Andréa Maria Cappellano, Éric Bouffet, Jonathan L. Finlay, Kevin Ginn, Claire Mazewski, Martin Mynarek, Andrés Morales-La Madrid, Valérie Larouche, Stephan Tippelt, Sabine Mueller, Lindsey M. Hoffman, Bruce Crooks, Mohamed Shebl Abdelbaki, Sébastien Perreault, Zhihong Wang, Sara Khan, Michal Zápotocký, Simon Bailey, Steven C Clifford, Kara Matheson
article en
2 citations

Abstract

Survival of patients with relapsed SHH iMB is not satisfactory and relies on treatments associated with toxicities including CSI and/or HDC + AuHCR. Cure at initial diagnosis to avoid relapse is crucial. For patients with localized relapse undergoing resection, alternative salvage regimens that avoid high-dose CSI (>24 Gy) can be considered.

Neuro-OncologyVol. 27(8)
University of Southern California (US), Western University (CA), Dalhousie University (CA), Hospital Sant Joan de Déu Barcelona (ES), St. Jude Children's Research Hospital (US), Nationwide Children's Hospital (US), Royal Children's Hospital (AU), Mount Sinai Hospital (US), Children's Mercy Hospital (US), Children's Hospital of Philadelphia (US), Children's Hospital of Los Angeles (US), University of British Columbia (CA), Emory University (US), Universität Hamburg (DE), The University of Texas at San Antonio Health Science Center (US), University of Calgary (CA), University of California, San Francisco (US), Virginia Commonwealth University (US), University of Toronto (CA), University of Zurich (CH), Washington University in St. Louis (US), Charles University (CZ), Université Paris-Saclay (FR), King Hussein Cancer Center (JO), Garrahan Hospital (AR), Great Ormond Street Hospital (GB), Izaak Walton Killam Health Centre (CA), London Health Sciences Centre (CA), Women's and Children's Hospital (AU), Hospital for Sick Children (CA), Institut Gustave Roussy (FR), Alberta Children's Hospital (CA), Centre Hospitalier Universitaire Sainte-Justine (CA), Nova Scotia Health Authority (CA), National Cancer Centre Japan (JP), Cook Children's Medical Center (US), Support group for adolescents and children with cancer (BR), Mount Sinai Medical Center (US), Children's Hospital Colorado (US), University Hospital in Motol (CZ), University Hospital of Zurich (CH), Mount Sinai Hospital (US), Dell Children's Medical Center of Central Texas (US), University Medical Center Hamburg-Eppendorf (DE), Center for Cancer and Blood Disorders (US), Hospital Infantil Universitario Niño Jesús (ES), Essen University Hospital (DE), Phoenix Children's Hospital (US), University Children's Hospital Zurich (CH), Instituto de Oncologia do Paraná (BR), South Australian Health and Medical Research Institute (AU), SickKids Foundation (CA), Children's Healthcare of Atlanta (US), Children's Hospital of Western Ontario (CA), Murdoch Children's Research Institute (AU), BC Children's Hospital (CA), Sidney Kimmel Comprehensive Cancer Center (US), Children's Hospital of Richmond at VCU (US), Université Laval (CA), University College London (GB), The Ohio State University (US), The University of Adelaide (AU), Université de Montréal (CA), University of Newcastle Australia (AU), Newcastle University (GB), Universidade Federal de São Paulo (BR), The University of Texas Health Science Center at Houston (US), University of Colorado Denver (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 9%
Glioma Diagnosis and Treatment
3.25
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