GluR2 overexpression in ACC glutamatergic neurons alleviates cancer-induced bone pain in rats
These findings suggest that decreased surface GluR2 receptors in ACC glutamatergic neurons contribute to calcium activity and excessive excitability, thereby inducing CIBP in rats. Conversely, GluR2 overexpression in ACC glutamatergic neurons alleviates CIBP in rats. This study provides a new potential therapeutic approach for targeting the GluR2 receptor to alleviate CIBP for cancer patients.
Authors
- Guang‐Yin Xu (ORCID: https://orcid.org/0000-0002-5465-5892)
- Shu‐Fen Hu (ORCID: https://orcid.org/0000-0001-9561-8206)
- Jinrong Wei (ORCID: https://orcid.org/0000-0002-7009-2073)
- Futing Ba
- Guoqin Jiang (ORCID: https://orcid.org/0000-0002-5294-9360)
- Chenyang Yu (ORCID: https://orcid.org/0009-0000-6416-5742)
- Qiyan Feng
- M. Song (ORCID: https://orcid.org/0009-0001-3611-4443)
- Hailong Zhang (ORCID: https://orcid.org/0000-0003-2171-622X)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s10020-025-01183-9
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China