Identification and expression profile analysis of circRNAs associated with goat uterus with different fecundity during estrous cycle
Based on the analysis, we have established the expression profiles of circRNAs during the follicular and luteal phases, respectively. Furthermore, using various analytical methods and data from high- and low-yield experimental control groups over different periods, we have identified multiple circRNAs that affect the high reproductive capacity of goats. Through enrichment analysis of the host genes of these circRNAs, we have discovered several key candidate genes. These findings provide fundamental data for the study of the molecular mechanisms underlying the fecundity of goats and pave the way for future genetic improvement strategies.
Authors
- Meiying Fang (ORCID: https://orcid.org/0000-0001-8732-745X)
- Mingxing Chu (ORCID: https://orcid.org/0000-0002-5164-0310)
- Xiaoyun He (ORCID: https://orcid.org/0000-0002-2159-5635)
- Lin Tao (ORCID: https://orcid.org/0000-0002-8954-5706)
- Yufang Liu (ORCID: https://orcid.org/0000-0001-7645-586X)
- Xiaolong Du (ORCID: https://orcid.org/0000-0001-9487-2894)
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12864-025-11489-x
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Chinese Academy of Agricultural Sciences
- Agricultural Science and Technology Innovation Program