Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling
The findings of this study suggest that rAT alleviates lung injury and suppresses inflammatory responses by inhibiting the IL17a/NF-κB signaling axis, suggesting that rAT may serve as a potential therapeutic agent for mitigating pulmonary inflammation and improving the prognosis of ARDS induced by sepsis. Furthermore, this study provides important research data and theoretical basis for the clinical translation and application of rAT.
Authors
- Mengxue Wang (ORCID: https://orcid.org/0000-0002-0756-7427)
- Lichen Guo
- Bing Yu (ORCID: https://orcid.org/0000-0002-3421-8601)
- Huiting Zhu
- Dongxu Li (ORCID: https://orcid.org/0000-0003-1440-7293)
- Junbo Zheng (ORCID: https://orcid.org/0009-0002-0569-5764)
- Haoxuan Li (ORCID: https://orcid.org/0000-0002-3486-3643)
- Chen Yang (ORCID: https://orcid.org/0000-0001-7153-3267)
- Yang Gao (ORCID: https://orcid.org/0000-0002-0612-0818)
- Cong Fu (ORCID: https://orcid.org/0009-0009-0905-2564)
- Qingqing Dai
Institutions
- Shanghai Medical College of Fudan University (CN)
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/itt.s502925
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00