Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming
TMQ0153 targets mitochondrial dynamics by inhibiting OPA1, inducing metabolic reprogramming, and triggering apoptosis in AML cells. It enhances the efficacy of existing AML therapies and provides a promising combination treatment approach that exploits mitochondrial vulnerability and metabolic reprogramming to improve treatment outcomes in AML.
Authors
- Anne Lorant (ORCID: https://orcid.org/0000-0001-5918-923X)
- Jinyoung Byun (ORCID: https://orcid.org/0000-0001-8579-1435)
- Byung Woo Han (ORCID: https://orcid.org/0000-0001-7571-3791)
- Marc Diederich (ORCID: https://orcid.org/0000-0003-0115-4725)
- David Kum
- Jin Mo Kang (ORCID: https://orcid.org/0000-0002-1477-9778)
- Ali Al‐Mourabit (ORCID: https://orcid.org/0000-0002-1762-6910)
- Michaël Schnekenburger (ORCID: https://orcid.org/0000-0003-0550-9538)
- Christo Z. Christov (ORCID: https://orcid.org/0000-0002-4481-0246)
- Juyong Lee (ORCID: https://orcid.org/0000-0003-1174-4358)
- Barbora Orlikova-Boyer
- Claudia Cerella (ORCID: https://orcid.org/0000-0001-9308-8176)
- Su Jung Park (ORCID: https://orcid.org/0000-0002-6122-0790)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie des Substances Naturelles (FR)
- Seoul National University (KR)
- Inserm (FR)
- University of Luxembourg (LU)
- Université Paris-Saclay (FR)
- Hôpital Kirchberg (LU)
- Luxembourg Institute of Health (LU)
- National University College (PR)
- Arbed (Luxembourg) (LU)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s13046-025-03372-0
- Citations
- 5
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Seoul National University
- National Research Foundation of Korea
- Centre National de la Recherche Scientifique
- Action LIONS Vaincre le Cancer
- Recherches Scientifiques Luxembourg
- Fondation Recherche Cancer et Sang
- Ministry of Science and ICT, South Korea