Topological Design of Pyrene‐Based Metal‐Organic Framework Nanosheets as a Luminescent Thermometer for Live Bioimaging
Abstract Metal−organic frameworks (MOFs) represent an attractive family of materials for diverse biomedical applications due to their porosity, chemical versatility, and stimuli‐responsive properties. Next to their drug delivery and bioimaging applications, MOFs have been recently considered as efficient luminescent thermal probes. However, the relatively low thermal sensitivity together with the biocompatibility of most MOF thermometers limits their practical applications. Here, a series of new MOFs based on Zn ions and a rectangular tetratopic ligand H 4 TBAPy (1,3,6,8‐tetrakis(p‐benzoic acid)pyrene) is reported, demonstrating a temperature‐dependent photoluminescence (PL) with up to 2.12% K −1 relative thermal sensitivities over the 7 – 300 K temperature range. Using a topological design approach, the structure of the obtained MOFs is tuned from two‐ to three‐dimensions via solvent exchange in order to build the optimal structure of the PL thermometer. Then, the resulting MOFs have been exfoliated to obtain MOF nanosheets (NSs) to be easily injected into living organisms. As a result, MOF NSs, intracardiac injected or introduced into the digestive system of the Casper fish, reveal a 100% survival rate together with an efficient in vivo PL thermometry of organs, thereby, paving the way to a rational design of highly sensitive and biocompatible MOF‐based thermometers.
Authors
- Maria Timofeeva (ORCID: https://orcid.org/0000-0002-8156-5411)
- Аndrei S. Potapov (ORCID: https://orcid.org/0000-0003-2360-7473)
- Anastasia Knyazeva (ORCID: https://orcid.org/0000-0001-8504-9126)
- Valentin A. Milichko (ORCID: https://orcid.org/0000-0002-8461-0804)
- Artem N. Abramov
- Sergei Alexandrovich Shipilovskikh (ORCID: https://orcid.org/0000-0002-8917-2583)
- Pascal Boulet (ORCID: https://orcid.org/0000-0003-0684-4397)
- Dmitry I. Pavlov (ORCID: https://orcid.org/0000-0002-5996-8062)
- Yuliya Kenzhebayeva (ORCID: https://orcid.org/0009-0001-8525-5437)
- Alexander S. Novikov (ORCID: https://orcid.org/0000-0001-9913-5324)
- Pavel V. Alekseevskiy (ORCID: https://orcid.org/0000-0003-0612-1260)
- Xiaolin Yu (ORCID: https://orcid.org/0009-0006-9717-2774)
- Н. В. Сомов (ORCID: https://orcid.org/0000-0001-9460-307X)
- Anastasiia S. Efimova (ORCID: https://orcid.org/0000-0002-6805-1280)
- Nikita Burzak
- Vyacheslav Dyachuk (ORCID: https://orcid.org/0000-0001-8100-7367)
- Nan Li (ORCID: https://orcid.org/0000-0001-9865-7577)
Institutions
- Perm State University (RU)
- Peoples' Friendship University of Russia (RU)
- Centre National de la Recherche Scientifique (FR)
- Tianjin University (CN)
- St Petersburg University (RU)
- ITMO University (RU)
- Dalian University of Technology (CN)
- Federal Almazov North-West Medical Research Centre (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- A.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences (RU)
- Nikolaev Institute of Inorganic Chemistry (RU)
- Institut Jean Lamour (FR)
- Saint Petersburg State Pediatric Medical University (RU)
- N. I. Lobachevsky State University of Nizhny Novgorod (RU)
- Université de Lorraine (FR)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/adfm.202425904
- Citations
- 3
- Primary Topic
- Metal-Organic Frameworks: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.61