A multi-functional synergistic platform of Cas12a split dsDNA activators
This work comprehensively explores the effects of various positions of Cas12a split activators. Based on this, a multi-functional synergistic platform was constructed. The construction of a structural dynamic network, the sensitive detection of APE1, and a time-controlled photo-activation have been achieved, demonstrating the potential for expanding Cas12a applications.
Authors
- Jiarun Wang
- Tongbo Wu (ORCID: https://orcid.org/0000-0002-6193-9017)
- Xiaolong Li (ORCID: https://orcid.org/0000-0001-6549-4089)
- Qin Xu (ORCID: https://orcid.org/0009-0002-7995-7528)
- Xianzhi Cheng
- Lan She
Institutions
- Guiyang Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01613d
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81