Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations
Our results support the development of HERG activators like ICA-105574 as promising pharmacological molecules against some severe LQT2 mutations and suggest that molecular dynamics simulations can be used to test the ability of molecules to modulate HERG function in silico, paving the way for the rational design of new HERG activators.
Authors
- Marco Denegri (ORCID: https://orcid.org/0000-0003-1665-0625)
- Carlo Camilloni (ORCID: https://orcid.org/0000-0002-9923-8590)
- Alessandro Trancuccio (ORCID: https://orcid.org/0000-0002-2181-8245)
- Giovanni Lentini (ORCID: https://orcid.org/0000-0001-7079-5994)
- Deni Kukavica (ORCID: https://orcid.org/0000-0002-7152-5934)
- Elisa Tavazzani (ORCID: https://orcid.org/0000-0002-0878-2524)
- Amit Kumawat (ORCID: https://orcid.org/0000-0001-6802-7398)
- Silvia G. Priori (ORCID: https://orcid.org/0000-0002-1093-235X)
- A. Oldani
Institutions
- University of Cagliari (IT)
- University of Milan (IT)
- University of Pavia (IT)
- Instituto de Salud Carlos III (ES)
- Istituti Clinici Scientifici Maugeri (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12929-025-01134-w
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Fondazione Telethon
- China Scholarship Council
- Università degli Studi di Pavia
- Technische Universität Darmstadt