Neuropilin‐1 as a Neuroinflammatory Entry Factor for SARS‐CoV‐2 Is Attenuated in Vaccinated COVID‐19 Patients: A Case–Control Study
The significant increase in the expression of NRP1 and IL-6 genes in COVID-19 patients, especially in moderate and severe cases, indicates their potential involvement in the progression of the disease, which may serve as biomarkers of disease severity. Also, since these genes play an important role in causing severe inflammation, cytokine storm, and immunopathological complications of COVID-19, further investigations maybe needed to achieve therapeutic goals to control COVID-19 and similar diseases.
Authors
- Mostafa Javanian (ORCID: https://orcid.org/0000-0002-2771-4578)
- Morteza Oladnabi (ORCID: https://orcid.org/0000-0001-7037-5084)
- Mohamadreza Ahmadifard (ORCID: https://orcid.org/0000-0003-3639-8703)
- Kiarash Saleki (ORCID: https://orcid.org/0000-0003-4159-7299)
- Moein Shirzad (ORCID: https://orcid.org/0000-0002-9725-3551)
- Abbas Azadmehr (ORCID: https://orcid.org/0000-0002-7698-9885)
- Faezeh Sadat Hosseini (ORCID: https://orcid.org/0000-0002-2960-0910)
Institutions
- Golestan University (IR)
- Universal Scientific Education and Research Network (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Babol University of Medical Sciences (IR)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/hsr2.70630
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Babol University of Medical Sciences