In vitro anti diabetic activity of PVA encapsulated silver nanoparticles of ethanolic extract of Pisonia grandis leaves

Diabetes mellitus is a chronic metabolic ailment that progresses beyond a person's lifetime. It is brought on by a relative shortage of insulin synthesis, leading to variable degrees of insulin resistance. The present study involves biosynthesis of poly vinyl alcohol (PVA) encapsulated silver nanoparticles of ethanolic extract of Pisonia grandis leaves (PVA AgNPs Pg) along with the evaluation of their potential biomedical applications. Analytical techniques like UV spectroscopy, XRD, SEM, EDX, TEM, FTIR and Zeta potential measurement were employed to assess the separated silver nanoparticles. PVA AgNPs Pg was also used to investigate the anti-diabetic effect in vitro. These studies have showed significant efficacy in inhibiting the enzymes DPPIV, alpha-amylase and alpha-glucosidase. Therefore, it is reasonable to conclude that silver nanoparticles fabricated by green synthesis might be used as a phytomedicine to treat diabetes.