Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization
These results indicated that Sitagliptin phosphate reduced high glucose-induced inflammation by improving the imbalance of macrophage polarization via modulating the mTORc1/ PPAR-γ/NF-κB <i>in vitro</i> and <i>in vivo</i>.
Authors
- Xiaoxia Hu (ORCID: https://orcid.org/0000-0002-2719-3805)
- Yalong Li (ORCID: https://orcid.org/0000-0003-1519-1690)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-2145-1674)
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fendo.2025.1544684
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Natural Science Foundation of Gansu Province