The gut microbiota in mice with erythropoietin—induced abdominal aortic aneurysm
EPO-induced gut dysbiosis, particularly changes in <i>Akkermansia, Lactobacillus,</i> and <i>Alistipes</i> abundance, may contribute to AAA formation via inflammation, oxidative stress, and metabolic dysfunction. While this model advances AAA research, its limitations underscore the need for human validation and mechanistic studies. Future work should prioritize multi-omics integration and cross-model comparisons to unravel the complex microbiota-AAA axis.
Authors
- Xianpeng Dai (ORCID: https://orcid.org/0000-0001-9815-294X)
- Xuanxin Lyu (ORCID: https://orcid.org/0000-0003-1841-6306)
- Xilian Liu
- Qi Liu (ORCID: https://orcid.org/0000-0002-4053-4213)
- Ming Jiang (ORCID: https://orcid.org/0000-0003-1417-360X)
- Yulan Li (ORCID: https://orcid.org/0000-0002-4270-1118)
- Jiahao Shi (ORCID: https://orcid.org/0009-0009-0740-161X)
- Shu‐Qin Ding
Institutions
- Anhui University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- University of South China (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-04-07
- DOI
- https://doi.org/10.7717/peerj.19222
- Citations
- 1
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Natural Science Foundation of Hunan Province