Limbic system abnormalities in episodic cluster headache: a 7T MRI multimodal study
Our findings demonstrate that in-bout but outside the attacks eCH patients present anatomical and functional maladaptation of the limbic system. Moreover, the observed dissociation between localized abnormalities and largely preserved network coupling-except in the hypothalamus and thalamus-suggests that these two regions may be particularly susceptible to eCH-related dysfunction, while broader brain networks retain compensatory capacity in pathological states. These findings refine potential neuromodulation targets and highlight the value of ultrahigh-field imaging in eCH research.
Authors
- Caohui Duan (ORCID: https://orcid.org/0000-0002-3470-5602)
- Xin Lou (ORCID: https://orcid.org/0000-0003-2980-5171)
- Zhao Dong (ORCID: https://orcid.org/0000-0002-4581-2569)
- Song Wang (ORCID: https://orcid.org/0000-0002-3457-6716)
- Mengmeng Hou (ORCID: https://orcid.org/0000-0001-9961-8473)
- Yongqin Xiong (ORCID: https://orcid.org/0000-0002-2435-9064)
- Haoxuan Lu
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-3173-6390)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0003-2104-7089)
- Shuhua Zhang (ORCID: https://orcid.org/0000-0002-5748-0637)
- Zhi‐Xuan Li (ORCID: https://orcid.org/0000-0002-8590-875X)
- Lu‐Hua Zhang (ORCID: https://orcid.org/0000-0003-0298-9388)
- Jiayu Huang (ORCID: https://orcid.org/0009-0005-3144-3108)
- Yan Li (ORCID: https://orcid.org/0009-0004-2353-2453)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s10194-025-02009-z
- Citations
- 7
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China