Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis
Gliomas are associated with significant glymphatic dysfunction, as evidenced by reduced DTI-ALPS indices and increased CSF and PTBE volumes. The DTI-ALPS index serves as a potential biomarker of glymphatic disruption in glioma patients, offering insights into tumor-related fluid changes and the pathophysiology of brain-tumor interactions.
Authors
- Haibo Xu (ORCID: https://orcid.org/0000-0002-8451-8979)
- Changyou Long
- Chunyan Li (ORCID: https://orcid.org/0000-0002-8382-5264)
- Dan Xu (ORCID: https://orcid.org/0000-0001-9128-5328)
- Wenbo Sun (ORCID: https://orcid.org/0000-0002-7364-4419)
- Jie Zhou (ORCID: https://orcid.org/0000-0001-7576-2817)
- Weiqiang Liang
- Huan Li (ORCID: https://orcid.org/0000-0003-4302-5120)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Cancer Imaging
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s40644-025-00868-y
- Citations
- 7
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 6.36
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province