THROMBOLYTIC POTENTIAL AND ANTIOXIDANT EFFICACY OF NELUMBO NUCIFERA LEAF EXTRACT

Thrombosis, the formation of blood clots in blood vessels, plays a key role in serious medical conditions such as cardiac arrest, deep vein thrombosis, lung embolism and ischemic stroke. Though, conventional thrombolytic agents like tissue plasminogen activators and streptokinase are effective, they often pose significant risks including severe bleeding and allergic reactions. To explore safer therapeutic alternatives, this study investigated the thrombolytic and antioxidant properties of the ethanolic extract from Nelumbo nucifera lotus leaves. In vitro analysis showed significant thrombolytic activity, with clot lysis reaching 94.34 % at 500 µg mL-1. Free radical scavenging activity was assessed by DPPH assay, which revealed strong activity with an IC50 of 24.19 µg mL-1, which is almost near to ascorbic acid. These results suggest that N. nucifera leaf extract, rich in bioactive compounds, offers promise as a natural alternative and adjunctive therapy for managing thrombotic disorders.