RNA-sequencing demonstrates transcriptional differences between human vocal fold fibroblasts and myofibroblasts
Transcriptomics of normal fibroblasts differ from myofibroblasts, including from those retrieved from scar and those treated with TGF-β1. Despite large differences in transcriptomics between tVFF and sVFF, tVFF serve as a useful in vitro model of myofibroblasts and highlight key similarities to myofibroblasts extracted from scar pathology, as well as expected differences related to normal fibroblasts from healthy vocal folds.
Authors
- Susan L. Thibeault (ORCID: https://orcid.org/0000-0002-9046-4356)
- Michelle Bretl (ORCID: https://orcid.org/0000-0003-0930-0985)
- Christina Kendziorski (ORCID: https://orcid.org/0000-0002-0700-6267)
- Lingxin Cheng
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s12864-025-11533-w
- Citations
- 2
- Primary Topic
- Voice and Speech Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders
- National Institute of General Medical Sciences