Research Progress of Gout Treated by Traditional Chinese Medicine

痛风性关节炎(Gouty Arthritis, GA)作为一种代谢性疾病，其病理基础集中于嘌呤代谢异常及尿酸排泄障碍为核心病理机制。当代临床实践表明，中医药干预策略在疾病管理中具有显著优势，尤其在疗效持久性和药物耐受性方面较传统化学药物表现突出。本文查阅近年来相关文献，从病因病机、中药内服与外治、单味药与复方治疗痛风的机制等方面进行综述，发现临床上常用中药内服以及中药外敷、刺络放血、针刀镜等治疗痛风性关节炎，方法多样，效果显著。在实验研究中，中医药治疗痛风性关节炎的机制与降低血尿酸、调节炎症细胞因子水平、抗氧化应激反应等密切相关。Gouty Arthritis (GA) is a metabolic disease, and its pathological basis focuses on abnormal purine metabolism and uric acid excretion. Contemporary clinical practice shows that the intervention strategy of traditional Chinese medicine has obvious advantages in disease management, especially in the durability of curative effect and drug tolerance. In this paper, the related literatures in recent years were reviewed from the aspects of etiology and pathogenesis, internal and external treatment of traditional Chinese medicine, and the mechanism of treating gout with single medicine and compound medicine. It was found that there were various methods and remarkable effects in treating gouty arthritis with internal and external application of traditional Chinese medicine, pricking collaterals and bloodletting, and needle knife mirror. In the experimental study, the mechanism of treating gouty arthritis with traditional Chinese medicine is closely related to reducing serum uric acid, regulating the level of inflammatory cytokines, and resisting oxidative stress.