Utilizing an attritor mill for solvent-free mechanochemical synthesis of <i>rac</i>-ibuprofen:nicotinamide co-crystals
The study demonstrates the efficient, solvent-free mechanochemical synthesis of rac -ibuprofen:nicotinamide co-crystals using an attritor mill, achieving a 99% yield of high-purity co-crystals in 30 min.
Authors
- Frederik Winkelmann (ORCID: https://orcid.org/0000-0002-9220-4486)
- Jan‐Hendrik Schöbel (ORCID: https://orcid.org/0000-0002-0966-1628)
- Michael Felderhoff (ORCID: https://orcid.org/0000-0001-9526-3943)
- Sarah Triller
Institutions
- Max-Planck-Institut für Kohlenforschung (DE)
Publication Details
- Journal
- RSC Mechanochemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5mr00020c
- Citations
- 1
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- European Commission
- HORIZON EUROPE Framework Programme