Lack of a Causal Association between DNA Methylation GrimAge Acceleration and Brain Tumor Incidence: A Two-Sample Mendelian Randomization Study
Our results do not support a causal association between GrimAge acceleration and brain tumor incidence. Accelerated epigenetic aging, as measured by GAA, may not be a direct driver of brain tumor risk. Further investigations should explore other epigenetic or genetic factors implicated in brain tumor etiology.
Authors
- Xiaobo Sun (ORCID: https://orcid.org/0000-0001-9876-5666)
- Xinlei Yang (ORCID: https://orcid.org/0000-0003-0771-7904)
- Jiming Sun
- Han Gao (ORCID: https://orcid.org/0009-0007-5410-8884)
- Yong Du (ORCID: https://orcid.org/0000-0002-4187-3989)
- Guojun Wei
- S. Bao
- Yu Fan (ORCID: https://orcid.org/0000-0003-3409-3471)
Institutions
- Beihua University (CN)
- People 's Hospital of Jilin Province (CN)
- Jilin City Central Hospital (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Shanghai Eighth People Hospital (CN)
- Tonghua Normal University (CN)
Publication Details
- Journal
- Journal of Multidisciplinary Healthcare
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jmdh.s503539
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00