Py-Azo-decorated covalent organic frameworks as a structure-responsive mass spectrometry probe for high-sensitivity and high-throughput screening of trace toxic chemicals in complex samples
A Py-azo-decorated covalent organic framework (Py-Azo-COF) was utilized as a structure-responsive probe for SALDI-TOF MS analysis. Benefiting from its unique structure, the Py-Azo-COF probe exhibited high affinity, sensitivity (LOD: 2-200 fg mL<sup>-1</sup>), reproducibility, salt tolerance, and low background interference, enabling efficient screening of diverse trace toxic chemicals in complex samples.
Authors
- Qiurong He
- Zunzhen Zhang (ORCID: https://orcid.org/0000-0002-3036-7124)
- Li Huang (ORCID: https://orcid.org/0000-0002-2908-1313)
- Qian Wang (ORCID: https://orcid.org/0000-0002-1608-163X)
- Xiu F. Huang (ORCID: https://orcid.org/0009-0002-1136-7599)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01108f
- Primary Topic
- Covalent Organic Framework Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00