GTS-21 alleviates sepsis-induced atrial fibrillation susceptibility by modulating macrophage polarization and Neuregulin-1 secretion
GTS-21 mitigated atrial inflammation and reduced the incidence of AF in mice with sepsis by regulating macrophage polarization, reducing oxidative stress, and preserving mitochondrial and calcium dynamics in cardiomyocytes. These findings highlight the therapeutic potential of GTS-21 in treating sepsis-induced AF.
Authors
- Siyuan Tan (ORCID: https://orcid.org/0000-0002-7729-1323)
- Jiabao Zhou
- Fanqi Li (ORCID: https://orcid.org/0000-0003-1936-8406)
- Yingxu Ma
- Qiming Liu (ORCID: https://orcid.org/0000-0002-3424-7234)
- Qiuzhen Lin (ORCID: https://orcid.org/0000-0003-2415-0401)
- Tao Tu (ORCID: https://orcid.org/0000-0002-7992-4526)
- Zixi Zhang
- Keke Wu (ORCID: https://orcid.org/0000-0002-3032-6963)
- Chonghua Wan (ORCID: https://orcid.org/0000-0002-7323-6837)
- Jiayi Zhu (ORCID: https://orcid.org/0009-0000-4094-1735)
- Yong Zhou
- Shunyi Li (ORCID: https://orcid.org/0000-0002-9565-4407)
- Gaoming Zeng (ORCID: https://orcid.org/0009-0005-9215-6073)
- Yusha Zhang
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.intimp.2025.114561
- Citations
- 12
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 15.82