3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study
The <i>HMGCR</i> variants exhibited significant associations with TC, LDL-C, and non-HDL-C levels as well as causally with DM risk in our Taiwanese population. <i>HMGCR</i> genotypes may play an important role and serve as a reference for the prevention and treatment of cardiovascular diseases in the clinical settings.
Authors
- Yu‐Lin Ko (ORCID: https://orcid.org/0000-0002-8218-6827)
- De‐Min Duan
- Lung‐An Hsu (ORCID: https://orcid.org/0000-0002-0012-2804)
- Kun‐Huei Yeh (ORCID: https://orcid.org/0000-0002-7306-174X)
- Semon Wu (ORCID: https://orcid.org/0000-0002-4544-9130)
- Ming-Sheng Teng
Institutions
- Chang Gung University (TW)
- Tzu Chi University (TW)
- Chinese Culture University (TW)
- Chang Gung Memorial Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
Publication Details
- Journal
- Tzu Chi Medical Journal
- Published
- 2025-04-01
- DOI
- https://doi.org/10.4103/tcmj.tcmj_247_24
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01