Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation
CT has anti-obesogenic, anti-inflammatory, and anti-hyperlipidemic properties mediated by its protective effects on the intestinal epithelium in obesity. Thus, our results highlight the promising preclinical results of CT treatment as a protective agent against the detrimental effects of HFD and LPS in mice.
Authors
- Priscila Romano Raimundo
- Luís Antônio Justulin (ORCID: https://orcid.org/0000-0001-6142-3515)
- Gabriela Bueno (ORCID: https://orcid.org/0000-0002-1546-601X)
- Clélia Akiko Hiruma-Lima (ORCID: https://orcid.org/0000-0002-8645-3777)
- Alba Rodríguez‐Nogales (ORCID: https://orcid.org/0000-0003-1927-0628)
- Felipe Lima Dario (ORCID: https://orcid.org/0000-0002-1957-6152)
- Maycon Tavares Emílio-Silva (ORCID: https://orcid.org/0000-0001-5466-3414)
- Antonio Jesús Ruiz‐Malagón (ORCID: https://orcid.org/0000-0003-4323-650X)
- M. Fioravanti (ORCID: https://orcid.org/0000-0002-3707-3081)
- Renata Assunção
- Vinícius Peixoto Rodrigues (ORCID: https://orcid.org/0000-0002-9312-2431)
- Rie Ohara (ORCID: https://orcid.org/0000-0003-4430-0016)
- Lúcia Regina Machado da Rocha (ORCID: https://orcid.org/0000-0002-7911-3862)
- Matheus Naia Fioretto (ORCID: https://orcid.org/0000-0003-0138-7959)
- Júlio Gálvez (ORCID: https://orcid.org/0000-0001-6876-3782)
Institutions
- Universidad de Granada (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fphar.2025.1567217
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual Paulista