Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses
The present study identified PD-associated gene signatures of the substantia nigra and blood, and demonstrated that the reduced expression of <i>TUBB2A</i> in the blood is promising to predict PD. Our findings provide novel insight into the mechanisms underlying PD pathophysiology and the development of PD biomarkers.
Authors
- Ya-Dan Song
- Jian‐Hong Zhu (ORCID: https://orcid.org/0000-0001-9412-8264)
- Dan-Ni Liu
- Dao‐Lu Zhang (ORCID: https://orcid.org/0000-0002-3490-2585)
- Lei Cui (ORCID: https://orcid.org/0000-0003-2394-7451)
- Na-Na Hou
- Xiong Zhang (ORCID: https://orcid.org/0000-0002-9214-396X)
- Huihui Fan (ORCID: https://orcid.org/0000-0002-7356-6190)
- Ruqi Tang (ORCID: https://orcid.org/0000-0003-0890-9094)
- Haitao Luo
Institutions
- Wenzhou Medical University (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fnagi.2025.1540830
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province