Immunogenic cell death genes in single-cell and transcriptome analyses perspectives from a prognostic model of cervical cancer

Through an integrated analysis of single-cell data, transcriptomic profiling, and computational modeling, seven ICD-related genes were identified as highly prognostic for CESC patients. Multivariate analysis demonstrated that low-risk patients had significantly better overall survival compared to high-risk patients, confirming the model as an independent prognostic tool. Assessments of the tumor microenvironment (TME), mutation characteristics, and drug sensitivity within ICDRs risk subgroups indicated a stronger immunotherapy response in the low-risk group.