Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs
These findings suggest that MA-5 is a viable treatment option for ARHL and other age-related disorders associated with mitochondrial dysfunction.
Authors
- Fan‐Yan Wei (ORCID: https://orcid.org/0000-0002-4843-724X)
- Kazuhito Tomizawa (ORCID: https://orcid.org/0000-0002-5663-2627)
- Toru Miwa (ORCID: https://orcid.org/0000-0002-5977-0056)
- Kishiko Sunami
- Teppei Kouga
Institutions
- Tohoku University (JP)
- Kyoto University (JP)
- Teikyo University Hospital (JP)
- Osaka Metropolitan University (JP)
- Tokyo Metropolitan University (JP)
- Teikyo University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fncel.2025.1541347
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81