Iron–Cobalt Dual Catalysis for the Synthesis of Alkenyl Amino Acids and Modification of Peptides
Herein, we report an Fe/Co dual-catalyzed strategy for synthesizing alkenyl unnatural amino acids and peptide modifications. This approach utilizes aspartic acid and glutamic acid derivatives as alkyl radical precursors. It avoids the use of expensive photoredox catalysts and substrate preactivation while preserving the chirality of the amino acids. Furthermore, this strategy enables both modification of peptides and the synthesis of amino-acid-based drug candidates for boron-neutron capture therapy (BNCT).
Authors
- Xu-Gang Zhang
- Peng‐Fei Xu (ORCID: https://orcid.org/0000-0002-5746-758X)
- Yong‐Chun Luo (ORCID: https://orcid.org/0000-0002-9567-7297)
- Haowen Jiang (ORCID: https://orcid.org/0000-0003-4419-7645)
- Huan-Huan Zhao (ORCID: https://orcid.org/0009-0003-1361-4482)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1021/acs.orglett.5c00888
- Citations
- 7
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Science and Technology Department of Xinjiang Uygur Autonomous Region
- National Natural Science Foundation of China
- Science and Technology Department of Gansu Province
- Higher Education Discipline Innovation Project