S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling
SPRC-modulated macrophage polarization alleviates TMJ-OA via JAK/STAT downregulation, thereby reducing synovial inflammation and cartilage degradation. These findings position SPRC as a promising therapeutic candidate for TMJ-OA and provide insights into novel strategies targeting macrophage polarization and synovium-cartilage crosstalk.
Authors
- Rui Li (ORCID: https://orcid.org/0009-0007-0894-1947)
- Kun Zheng (ORCID: https://orcid.org/0009-0002-2930-8896)
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Antong Wu
- Richard T. Jaspers (ORCID: https://orcid.org/0000-0002-6951-0952)
- Yi Zhun Zhu (ORCID: https://orcid.org/0000-0001-7700-8041)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6812-7356)
- Xin Li (ORCID: https://orcid.org/0000-0003-2999-9818)
- Qingbin Zhang (ORCID: https://orcid.org/0000-0002-8523-9293)
- Wei Cao (ORCID: https://orcid.org/0000-0002-8546-6090)
- Zhongxiao Lin (ORCID: https://orcid.org/0000-0002-0440-8949)
- Na Zhou (ORCID: https://orcid.org/0000-0001-6211-2946)
- Yufu Lin
- Wenyi Cai
Institutions
- Macau University of Science and Technology (MO)
- Stomatology Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Vrije Universiteit Amsterdam (NL)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s10020-025-01186-6
- Citations
- 15
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 11.96
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Fundo para o Desenvolvimento das Ciências e da Tecnologia