Quantification of perforant path fibers for early detection of Alzheimer's disease
Twenty post mortem brain tissues were scanned with 11.7T MRI. Degeneration of PP fibers was observed at 250 µm isotropic resolution. PP fiber indices were linked with severities of NFTs. The number of PP fibers was decreased in preclinical AD.
Authors
- Kenichi Oishi (ORCID: https://orcid.org/0000-0002-1200-8611)
- Laura Gómez-Isaza
- Michael I. Miller (ORCID: https://orcid.org/0000-0003-4689-3855)
- Marianna Luongo (ORCID: https://orcid.org/0000-0001-7325-1984)
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Zhipeng Hou (ORCID: https://orcid.org/0000-0001-8119-8052)
- Yuto Uchida (ORCID: https://orcid.org/0000-0002-6521-0784)
- Susumu Mori
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Precision for Medicine (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70142
- Citations
- 9
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 12.24