Immune Checkpoint Inhibitor–Induced Ocular Myasthenia Gravis: Case Series and Literature Review

ICI-OMG is a rare and distinct condition, presenting significant diagnostic challenges due to often negative antibody tests and variable sfEMG results. Early recognition of ICI-OMG in patients with ptosis and/or diplopia is crucial. Treatment responses vary, and most patients do not return to baseline, indicating ICI-OMG is likely chronic. Further research is needed to improve diagnostic markers and treatment strategies.

Authors

Publication Details

Journal
Journal of Neuro-Ophthalmology
Published
2025-04-07
DOI
https://doi.org/10.1097/wno.0000000000002330
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
Field-Weighted Citation Impact
0.00
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article

Immune Checkpoint Inhibitor–Induced Ocular Myasthenia Gravis: Case Series and Literature Review

Wayne T. Cornblath, Victoria Dezard, Edward Margolin, Heather M. McDonald
1 links
Journal of Neuro-Ophthalmology
Myasthenia Gravis and Thymoma
article

Immune Checkpoint Inhibitor–Induced Ocular Myasthenia Gravis: Case Series and Literature Review

Wayne T. Cornblath, Victoria Dezard, Edward Margolin, Heather M. McDonald
article en

Abstract

ICI-OMG is a rare and distinct condition, presenting significant diagnostic challenges due to often negative antibody tests and variable sfEMG results. Early recognition of ICI-OMG in patients with ptosis and/or diplopia is crucial. Treatment responses vary, and most patients do not return to baseline, indicating ICI-OMG is likely chronic. Further research is needed to improve diagnostic markers and treatment strategies.

Journal of Neuro-OphthalmologyVol. 46(1)
Good health and well-being
Openalex Percentile: Top 89%
Myasthenia Gravis and Thymoma
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