Miltirone enhances the chemosensitivity of gastric cancer cells to cisplatin by suppressing the PI3K/AKT signaling pathway
Miltirone inhibited the proliferation of GC cells and significantly potentiates the anticancer activities of cisplatin by downregulating the PI3K/AKT signaling pathway. Combination therapy of miltirone and cisplatin represents a novel potential treatment of gastric cancer.
Authors
- Hang Lv (ORCID: https://orcid.org/0000-0003-0635-4929)
- Yiping Wang (ORCID: https://orcid.org/0000-0002-7730-8906)
- Li Shen (ORCID: https://orcid.org/0000-0003-1555-7584)
- Zhe Chen (ORCID: https://orcid.org/0000-0002-3764-1587)
Institutions
- Zhejiang Chinese Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fphar.2025.1553791
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences
- Natural Science Foundation of Zhejiang Province