Global research trends in biomarkers, therapeutic targets, and drugs for amyotrophic lateral sclerosis: a bibliometric and visualization analysis
The United States dominates ALS research productivity, whereas the United Kingdom demonstrates superior citation influence. Despite China's substantial publication volume, its limited citation impact underscores the necessity for enhanced methodological rigor and strategic international collaboration. Current research priorities encompass NfL, TMS, and ASO therapies, with emerging innovations in stem cell therapy, BBB penetration technologies and skeletal muscle targeting showing therapeutic promise. Future directions should prioritize biomarker standardization, optimization of drug delivery systems, and Clinical Translation.
Authors
- K. J. Zhu (ORCID: https://orcid.org/0000-0002-4365-8043)
- Jianliang Huang (ORCID: https://orcid.org/0000-0003-1264-7349)
- Weicheng Huang (ORCID: https://orcid.org/0000-0002-6071-3411)
- Ying Liu (ORCID: https://orcid.org/0000-0001-7710-0809)
- Na Guo (ORCID: https://orcid.org/0009-0003-8137-5700)
- Gao Wei (ORCID: https://orcid.org/0000-0002-7583-9754)
Institutions
- Central South University (CN)
- Jishou University (CN)
- Ministry of Education (SA)
- Hunan Cancer Hospital (CN)
- Ministry of Education (ET)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fphar.2025.1588968
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39