Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration
Our findings reveal a novel mechanism by which GAP-43 activity is regulated through phosphorylation at calcineurin-sensitive sites. These findings suggest that FK506's neuroprotective effects may be partially mediated through GAP-43 phosphorylation, providing a potential target for therapeutic intervention in synucleinopathies.
Authors
- Ekaterina A. Grebenik (ORCID: https://orcid.org/0000-0002-0763-2903)
- Gabriela Caraveo (ORCID: https://orcid.org/0000-0001-9512-3449)
- Sofia Zaichick (ORCID: https://orcid.org/0000-0001-6816-5926)
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fnagi.2025.1566465
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Parkinson's Foundation