Association of genetic risk score for Alzheimer's disease with late‐life body mass index in all of us: Evaluating reverse causation
Understanding when physiological changes from amyloid pathology begin is key for AD prevention. Our findings indicate that AD-associated genes accelerate midlife weight loss, starting between 47 and 54 years. AD prevention research should consider that disease pathology likely begins by middle age.
Authors
- M. Maria Glymour (ORCID: https://orcid.org/0000-0001-9644-3081)
- Katrina Kezios (ORCID: https://orcid.org/0000-0001-7115-032X)
- Scott C. Zimmerman (ORCID: https://orcid.org/0000-0002-4431-6520)
- Minhyuk Choi (ORCID: https://orcid.org/0009-0000-6658-5054)
- Willa D. Brenowitz
- Peter Buto (ORCID: https://orcid.org/0000-0001-5052-6009)
- Jingxuan Wang (ORCID: https://orcid.org/0000-0002-1570-7266)
- Thomas J. Hoffmann
- Adina Zeki Al Hazzouri (ORCID: https://orcid.org/0000-0002-6006-321X)
Institutions
- Boston University (US)
- University of California, San Francisco (US)
- Kaiser Permanente Center for Health Research (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.14598
- Citations
- 3
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Institutes of Health
- National Institute on Aging