Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01
Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) <sup>13</sup>C NMR chemical shifts, electronic circular dichroism (ECD), and spin-spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.
Authors
- Wen‐Xuan Wang (ORCID: https://orcid.org/0000-0002-7391-2954)
- Jing Li (ORCID: https://orcid.org/0000-0001-8133-507X)
- Yan Li (ORCID: https://orcid.org/0000-0002-1699-2337)
- Ai-Lin Liang
- Wen-Yu Lu
- Yi-Yun Yuan
Institutions
- Central South University (CN)
- Hunan University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1007/s13659-025-00507-w
- Citations
- 5
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 6.97
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province