Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease
Platelets mirror several Alzheimer's disease (AD)-dependent neuronal changes, valuable for blood tests. As a start, 60 AD-associated frontal lobe proteins were identified by top-down proteomics. Fifty percent of these 60 AD-affected brain proteins are represented identically in platelets. Among these, glutathione S-transferase omega 1 (GSTO1), superoxide dismutase 1 (SOD1), copper chaperone for superoxide dismutase (CCS), and glutathione peroxidase 1 (GPX1) are identically AD related in brain and platelets. SOD1 and its crucial activating partner CCS are altered in the platelets of patients with mild cognitive impairment.
Authors
- Rudolf Oehler (ORCID: https://orcid.org/0000-0003-2891-7155)
- Christina Maria Reumiller
- Eduard Rappold (ORCID: https://orcid.org/0000-0002-6989-5506)
- Ellen Umlauf
- Ingrid Miller (ORCID: https://orcid.org/0000-0002-7192-0109)
- Jacqueline Mühlberger
- Maria Zellner (ORCID: https://orcid.org/0000-0003-2245-2158)
- Huriye Ercan (ORCID: https://orcid.org/0000-0001-8110-1556)
- Felicia Hsu
- Johannes Attems (ORCID: https://orcid.org/0000-0003-1636-1700)
- Georg Schmidt
Institutions
- University of Veterinary Medicine Vienna (AT)
- Newcastle Hospitals - Campus for Ageing and Vitality (GB)
- Medical University of Vienna (AT)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70117
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Alzheimer's Society
- European Commission
- FP7 People: Marie-Curie Actions