Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood–brain barrier disruption in Alzheimer's disease: an autopsy study
Changes in the median tunica and basement membrane-related ECM contents of the microvasculature were quantified in human brains. Venular collagenosis was significantly more severe in AD patients. In the AD group, BBB disruption and ECM remodeling were important contributors to AD neuropathological changes. Agrin disrupted the BBB by inducing ferroptosis in pericytes, which presents a potential new target.
Authors
- Chenhui Mao (ORCID: https://orcid.org/0000-0003-4086-659X)
- Chao Ma (ORCID: https://orcid.org/0000-0003-1346-6961)
- Yicheng Zhu (ORCID: https://orcid.org/0000-0003-3037-0398)
- Meiying Huang (ORCID: https://orcid.org/0000-0002-5031-7423)
- Xue Wang (ORCID: https://orcid.org/0000-0002-7423-362X)
- Yuan Cao (ORCID: https://orcid.org/0000-0003-4257-6908)
- Wenying Qiu (ORCID: https://orcid.org/0000-0003-4906-8746)
- Yuanyuan Xu (ORCID: https://orcid.org/0000-0003-3521-0115)
- Xiaojing Qian
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70103
- Citations
- 8
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- National Natural Science Foundation of China