White matter hyperintensity spatial patterns: Risk factors and clinical correlates
We studied spatial patterns of WMHs in 2878 participants. Blood pressure was associated with frontoparietal and anterior PV WMHs. Anterior PV WMHs predicted dementia and stroke risk. Juxtacortical-deep occipital WMH burden was not associated with blood pressure or WMH genetic risk. Juxtacortical-deep occipital WMH burden predicted dementia and intracerebral hemorrhage.
Authors
- Aniket Mishra (ORCID: https://orcid.org/0000-0002-8141-1543)
- Marc Joliot (ORCID: https://orcid.org/0000-0001-7792-308X)
- Arno Villringer (ORCID: https://orcid.org/0000-0003-2604-2404)
- Markus Loeffler (ORCID: https://orcid.org/0000-0002-0424-9933)
- Hélène Jacqmin‐Gadda (ORCID: https://orcid.org/0000-0002-7727-6625)
- Philippe Amouyel (ORCID: https://orcid.org/0000-0001-9088-234X)
- Ami Tsuchida (ORCID: https://orcid.org/0000-0001-5160-6203)
- A. Veronica Witte (ORCID: https://orcid.org/0000-0001-9054-6688)
- Hema Sekhar Reddy Rajula (ORCID: https://orcid.org/0000-0003-4667-8143)
- Christophe Tzourio (ORCID: https://orcid.org/0000-0002-6517-2984)
- Cécile Proust‐Lima (ORCID: https://orcid.org/0000-0002-9884-955X)
- Fabrice Crivello (ORCID: https://orcid.org/0000-0001-6950-984X)
- Markus Scholz (ORCID: https://orcid.org/0000-0002-4059-1779)
- Stéphanie Debette (ORCID: https://orcid.org/0000-0001-8675-7968)
- Frauke Beyer (ORCID: https://orcid.org/0000-0001-5401-852X)
- Carole Dufouil
- Aïcha Soumaré
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Lille (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Institut Pasteur de Lille (FR)
- Sorbonne Université (FR)
- Institut des Maladies Neurodégénératives (FR)
- Bordeaux Population Health (FR)
- Pitié-Salpêtrière Hospital (FR)
- University Hospital Leipzig (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Institut du Cerveau (FR)
- Leipzig University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70053
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Fondation Claude Pompidou
- Freistaat Sachsen
- European Regional Development Fund
- European Social Fund