Long-term effectiveness and safety of methotrexate-tacrolimus combination therapy versus methotrexate monotherapy in reducing rheumatoid arthritis flares after TNF inhibitor discontinuation: a retrospective cohort study
Methotrexate-tacrolimus combination therapy significantly reduces relapse risk following TNF inhibitor discontinuation without compromising safety, offering a potentially sustainable treatment alternative after achieving remission with TNF inhibitor therapy.
Authors
- Taio Naniwa (ORCID: https://orcid.org/0000-0002-0489-2611)
- Mikiko Kajiura
Institutions
- Nagoya City University (JP)
- Nagoya University Hospital (JP)
- Nagoya City University Hospital (JP)
- Noguchi Hospital (JP)
- Nagoya Medical Center (JP)
Publication Details
- Journal
- BMC Rheumatology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s41927-025-00489-9
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nagoya City University