Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis
BMI increases OA risk, with KD and TBMD partially mediating the effect, particularly for KOA. The direct impact of BMI remains predominant, emphasizing the importance of weight reduction, joint protection, and physical activity as preventive measures.
Authors
- Xin Xu (ORCID: https://orcid.org/0000-0003-3395-9923)
- Junxiang Wang (ORCID: https://orcid.org/0009-0002-4188-0932)
- Hui Li (ORCID: https://orcid.org/0000-0002-8438-0287)
- Junfei Guo
- Hui Yu (ORCID: https://orcid.org/0000-0003-3901-7187)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Aging Clinical and Experimental Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1007/s40520-025-03035-2
- Citations
- 7
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 12.72