Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer
The combination of anlotinib and aPD-L1 effectively modulates the HGSOC tumor microenvironment by inhibiting angiogenesis, enhancing immune infiltration, and reversing T cell exhaustion.
Authors
- Hongwei Lan
- Chuantao Zhang (ORCID: https://orcid.org/0000-0003-1212-971X)
- Xiaochun Zhang (ORCID: https://orcid.org/0000-0002-5394-3091)
- Na Zhou (ORCID: https://orcid.org/0000-0001-9488-4713)
- Hui Liu (ORCID: https://orcid.org/0000-0002-2222-1053)
- Jingjuan Zhu
- Helei Hou
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1539616
- Citations
- 3
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14